PD-L1 Expression as a Predictive Biomarker For Immune Checkpoint Inhibitors: Between a Dream And a Nightmare
Joseph Zouein, Carole Kesrouani, Hampig Raphaël Kourié
Abstract
PD-L1 is an important predictive biomarker for treatment by immune checkpoint inhibitors (ICIs). ICIs are now indicated for the treatment of various cancer depending on the level of expression of PD-L1 on tumor cells. PD-L1 testing is done using immunohistochemistry with five different assays approved as companion diagnostic for ICIs. However, these assays have different score reporting methods and do not accurately measure PD-L1 expression. Exosomal PD-L1 testing has recently emerged as an alternative for cell-surface PD-L1 testing however studies are still premature and more extensive knowledge about this new potential biomarker is needed.
Topics & Concepts
BiomarkerImmune checkpointImmunotherapyPD-L1MedicineImmune systemCancerCancer immunotherapyMalignancyNivolumabCancer researchOncologyImmunologyInternal medicineBiologyBiochemistryCancer Immunotherapy and BiomarkersCAR-T cell therapy researchCancer Genomics and Diagnostics