Intermittent Fasting Modulates Immune Response by Generating Tregs via TGF-β Dependent Mechanisms in Obese Mice with Allergic Contact Dermatitis
Sang-Chul Han, Jung-Il Kang, Youn Kyung Choi, Hye‐Jin Boo, Weon‐Jong Yoon, Hee‐Kyoung Kang, Eun-Sook Yoo
Abstract
T cells. These results indicate that the IF regimen enhances the TGF-β-producing ability of M2 macrophages and that the development of Tregs keeps mice healthy against ACD exacerbated by obesity. Therefore, the IF regimen may ameliorate inflammatory immune disorders caused by obesity.
Topics & Concepts
Immune systemImmunologyInflammationMedicineAdipose tissueRegimenTransforming growth factorT cellInternal medicineDietary Effects on HealthImmune Cell Function and InteractionAdipokines, Inflammation, and Metabolic Diseases