An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes
Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric F. Johnson, Sang Joon Won, Asako Nagata, Divya Bezwada, Matthew D. Petroski, Jaimeen D. Majmudar, Sherry Niessen, Todd VanArsdale, A. Gilbert, Matthew M. Hayward, Al Stewart, Andrew R. Nager, Bruno Melillo, Benjamin F. Cravatt
Topics & Concepts
Allosteric regulationCyclin-dependent kinase 2ChemistryCovalent bondCell biologyCyclin-dependent kinaseCyclin ACyclinBiophysicsBiologyComputational biologyKinaseBiochemistryCell cycleEnzymeGeneProtein kinase AOrganic chemistryClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid Chemistry