Cross-network coupling of neural oscillations in the dynamic pain connectome reflects chronic neuropathic pain in multiple sclerosis
Junseok A. Kim, Rachael L. Bosma, Kasey S. Hemington, Anton Rogachov, Natalie R. Osborne, Joshua C. Cheng, Jiwon Oh, Benjamin T. Dunkley, Karen D. Davis
Abstract
• Abnormal broadband cross-network brain communication in MS-related chronic pain. • Abnormal communication found between the salience network and other networks. • Neuropathic and non-neuropathic pain showed different patterns of abnormality. • Abnormal brain communication was linked to pain intensity and pain interference. • Alpha, beta and gamma bands may play a significant role in chronic pain. Sensory perceptions are coded by complex neural dynamics of regional communication in the brain. Thus, sensory abnormalities such as chronic pain may occur when neural dynamics go awry. Previous studies of cross-network dynamic functional connectivity in chronic pain identified abnormalities but were based on functional MRI which only captures slow temporal features. Here we conducted a magnetoencephalography (MEG) study to investigate fine temporal dynamics of aberrant cross-regional and cross-network communication of the dynamic pain connectome in patients with chronic pain. We also introduced a novel measure, dynamic functional coupling, to quantify the variability of brain communication. The study was performed in 33 people who had chronic pain associated with multiple sclerosis and 30 healthy controls. We found that patients with chronic pain exhibited abnormalities in cross-network functional coupling across multiple frequency bands (theta, alpha, beta, gamma), between the salience network and 3 other networks: the ascending nociceptive pathway, descending anti-nociceptive pathway, and the default mode network. However, these cross-network abnormalities involved different frequency bands in patients with neuropathic versus non-neuropathic chronic pain. Furthermore, cross-network abnormalities were linked to pain severity and pain interference. Our findings implicate broadband cross-network abnormalities as hallmark features of chronic pain in multiple sclerosis.