Telaprevir Treatment Reduces Paralysis in a Mouse Model of Enterovirus D68 Acute Flaccid Myelitis
Joshua Frost, Michael J. Rudy, J. Smith Leser, Haozhou Tan, Yanmei Hu, Jun Wang, Penny Clarke, Kenneth L. Tyler
Abstract
Recent outbreaks of EV-D68 in 2014, 2016, and 2018 have resulted in over 600 cases of a paralytic illness that is known as AFM. AFM is a predominantly pediatric disease with no FDA-approved treatment, and many patients show minimal recovery from limb weakness.
Topics & Concepts
BiologyVirologyAcute flaccid paralysisFlaccid paralysisParalysisTelaprevirMyelitisBotulismEnterovirusImmunologyVirusPoliovirusMedicineMicrobiologySpinal cordSurgeryHepatitis C virusNeuroscienceRibavirinViral Infections and Immunology ResearchViral gastroenteritis research and epidemiologyRespiratory viral infections research