Binaphthyl Scaffold: A Class of Versatile Structure in Asymmetric C–H Functionalization
Qiang Yue, Bin Liu, Gang Liao, Bing‐Feng Shi
Abstract
Over the past decades, transition metal-catalyzed enantioselective C–H functionalization has emerged as a straightforward and powerful tool for the rapid access to chiral molecules. The enormous advances achieved in this emerging area largely rely on the development of chiral ligands that can enable both high levels of enantiocontrol and efficiency. Chiral ligands bearing binaphthyl scaffolds have been proven to be versatile in asymmetric C–H functionalization due to their availability, unique stereochemical features, and ease of fine-tuning steric and electronic properties. In this Review, we summarized the advance in the applications of chiral ligands on the basis of the binaphthyl scaffold in asymmetric C–H functionalization.