Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential
Mirna Jovanović, Daniil Zhukovsky, Ana Podolski-Renić, Raivis Žalubovskis, Dmitry Dar’in, Vladimir V. Sharoyko, Tatiana Tennikova, Milica Pešić, Mikhail Krasavin
Topics & Concepts
Thioredoxin reductaseChemistryThioredoxinReductaseCell culturePharmacologyPotencyEnzymeIC50BiochemistryIn vitroBiologyGeneticsRedox biology and oxidative stressEnzyme function and inhibitionMetal-Catalyzed Oxygenation Mechanisms