Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia
Benjamin Gaston, Laura Smith, Michael D. Davis, Jessica Saunders, Ivana Daniels, Amjad Horani, Steven L. Brody, Olivia Giddings, Yi Zhao, Nadzeya Marozkina
2024American Journal of Physiology-Lung Cellular and Molecular Physiology11 citationsDOIOpen Access PDF
Abstract
The PCD airway epithelium does not optimally clear antigens, and antigen exposure can lead to NO oxidation and nitrosative stress. Oxidation caused by antigen stasis could represent a therapeutic target in PCD, and there are convenient monitoring biomarkers.
Topics & Concepts
Primary ciliary dyskinesiaAntigenRespiratory epitheliumChemistryOxidative stressImmunologyMolecular biologyRespiratory systemInternal medicineMedicineBiologyLungBronchiectasisBiochemistryCystic Fibrosis Research AdvancesAsthma and respiratory diseasesOlfactory and Sensory Function Studies