Truncated titin proteins in dilated cardiomyopathy
Quentin McAfee, Yingxian Chen, Yifan Yang, Matthew A. Caporizzo, Michael P. Morley, Apoorva Babu, Sunhye Jeong, Jeffrey Brandimarto, Kenneth Bedi, Emily Flam, Joseph Cesare, Thomas P. Cappola, Kenneth B. Margulies, Benjamin L. Prosser, Zoltàn Arany
Abstract
DCM hearts, and support combined dominant-negative and haploinsufficiency contributions to disease.
Topics & Concepts
TitinObscurinDilated cardiomyopathyHaploinsufficiencyCardiomyopathyBiologyMolecular biologyContractilityBlotCell biologySarcomereGeneticsMedicineMyocyteInternal medicineHeart failureEndocrinologyGenePhenotypeCardiomyopathy and Myosin StudiesViral Infections and Immunology ResearchRNA and protein synthesis mechanisms