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Catalytic synthesis of functionalized amidines<i>via</i>cobalt-carbene radical coupling with isocyanides and amines

Zheng‐Yang Gu, Hui Han, Ziyin Li, Shun‐Jun Ji, Ji‐Bao Xia

2021Organic Chemistry Frontiers16 citationsDOI

Abstract

An atom- and step-economic multi-component cobalt-catalyzed synthesis of amidines has been reported by using amines, isocyanides, and diazo compounds as carbene sources.

Topics & Concepts

ChemistryCarbeneDiazoCatalysisCobaltCombinatorial chemistryAtom economyIsocyanidePolymer chemistryOrganic chemistryPhotochemistryMedicinal chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions
Catalytic synthesis of functionalized amidines<i>via</i>cobalt-carbene radical coupling with isocyanides and amines | Litcius