Late-stage stitching enabled by manganese-catalyzed C─H activation: Peptide ligation and access to cyclopeptides
Nikolaos Kaplaneris, Felix Kaltenhäuser, Giedre Sirvinskaite, Shuang Fan, Tiago De Oliveira, Lena‐Christin Conradi, Lutz Ackermann
Abstract
Bioorthogonal late-stage diversification of structurally complex peptides bears enormous potential for drug discovery and molecular imaging. Despite major accomplishments, these strategies heavily rely on noble-metal catalysis. Herein, we report on a manganese(I)-catalyzed peptide C─H hydroarylation that enabled the stitching of peptidic and sugar fragments, under exceedingly mild and racemization-free conditions. This convergent approach represents an atom-economical alternative to traditional iterative peptide synthesis. The robustness of the manganese(I) catalysis regime is reflected by the full tolerance of a plethora of sensitive functional groups. Our strategy enabled an expedient access to challenging cyclic peptides by a modular late-stage macrocyclization of structurally complex peptides.