Lateral lithiation in deep eutectic solvents: regioselective functionalization of substituted toluene derivatives
Davide Arnodo, Simone Ghinato, Stefano Nejrotti, Marco Blangetti, Cristina Prandi
Abstract
The heteroatom-directed lateral lithiation of functionalized toluenes in a choline chloride-based eutectic mixture is reported. The metalations proceed within ultrafast reaction times, with a broad substrate and electrophile scope. The directing groups provide a rapid and high regioselective access to functionalized aromatic derivatives of remarkable synthetic value.
Topics & Concepts
RegioselectivityTolueneSurface modificationEutectic systemDeep eutectic solventChemistryOrganic chemistryCombinatorial chemistryCatalysisAlloyPhysical chemistryIonic liquids properties and applicationsCoordination Chemistry and OrganometallicsElectrochemical Analysis and Applications