Data resource: vasopressin-regulated protein phosphorylation sites in the collecting duct
Euijung Park, Chin‐Rang Yang, Viswanathan Raghuram, Venkatesh Deshpande, Arnab Datta, Brian G. Poll, Kirby T. Leo, Hiroaki Kikuchi, Lihe Chen, Chung‐Lin Chou, Mark A. Knepper
Abstract
Vasopressin regulates renal water excretion through control of the aquaporin-2 water channel in collecting duct cells. Studies of vasopressin-induced protein phosphorylation have focused mainly on the phosphorylation of aquaporin-2. This study describes 44 phosphoproteins other than aquaporin-2 that undergo vasopressin-mediated phosphorylation changes and summarizes potential physiological roles of each.
Topics & Concepts
VasopressinPhosphorylationAquaporin 2Protein phosphorylationAquaporin 3AquaporinChemistryCell biologyInternal medicineWater channelBiologyEndocrinologyProtein kinase AMedicineEngineeringMechanical engineeringInletIon Transport and Channel RegulationNeuroendocrine regulation and behaviorElectrolyte and hormonal disorders