Sesquiterpene glycoside isolated from loquat leaf targets gut microbiota to prevent type 2 diabetes mellitus in db/db mice
Ruoyun Wu, Lina Zhou, Yan Chen, Xiaoqin Ding, Yan Liu, Bei Tong, Han Lv, Xiuhua Meng, Jing Li, Tunyu Jian, Jian Chen
Abstract
• SG1 prevents obesity, ameliorates insulin resistance, and reduces systemic inflammation. • SG1 keeps the gut microbial diversity. •The efficacy of SG1 in the treatment of T2DM is strongly linked with the enhancement of several gut genera.
Topics & Concepts
LachnospiraceaeGut floraBiologyFirmicutesRoseburiaBacteroidetesMicrobiologyInsulin resistanceRuminococcusLactobacillusDiabetes mellitusBacteriaImmunologyEndocrinology16S ribosomal RNAGeneticsGut microbiota and healthGinger and Zingiberaceae researchPharmacological Effects of Natural Compounds