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Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Boehme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge Van de Walle, Stephanie Sontag, Jolien Vandewalle, Bart Vandekerckhove, Georges Leclercq, Pieter Van Vlierberghe, Claude Libert, Filip Van Nieuwerburgh, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Gina M. Doody, Martin Zenke, Tom Taghon

2023Nature Immunology22 citationsDOIOpen Access PDF

Topics & Concepts

Cell biologyHaematopoiesisBiologyIRF8LymphopoiesisStromal cellDendritic cellThymocyteT cellTranscription factorCytokinePrecursor cellImmunologyStem cellCellCancer researchImmune systemGeneGeneticsImmunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Cell Function and Interaction
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF | Litcius