Vaccine candidate designed against carcinoembryonic antigen-related cell adhesion molecules using immunoinformatics tools
Aditya Gupta, Andrew J Rosato, Feng Cui
Abstract
modeling. Molecular docking of epitopes to MHC structures have revealed that the lowest energy conformations are the epitopes bound to the antigen-binding groove of the MHC molecules. Subsequent molecular dynamics simulation has confirmed the stability of the binding conformations in solution. The predicted vaccine has relatively high antigenicity and low allergenicity, suggesting that it is an ideal candidate for further refinement and development.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
EpitopeAntigenicityDocking (animal)Carcinoembryonic antigenMajor histocompatibility complexMHC class IBiologyCancer immunotherapyAntigenCell biologyChemistryImmune systemImmunotherapyGeneticsCancerMedicineNursingvaccines and immunoinformatics approachesMonoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune Responses