Chiral Boro‐Phosphate Catalyzed Asymmetric Transfer Hydrogenation of 1‐Enal Substituted 2‐Naphthols: Access to Axially Chiral Styrene‐Type Allylalcohols
Hong‐Xin Jiang, Dandan Han, Rui‐Ping Song, Qin Shi, Xiao‐Fan He, Wan‐Qing Kou, Qi Zhao, You‐Dong Shao, Dao‐Juan Cheng
Abstract
Abstract Herein, we present a chiral boro‐phosphate catalyzed atroposelective asymmetric transfer hydrogenation method, leading to a family of axially chiral styrene‐type allylalcohols. This dynamic kinetic resolution approach portrays simple procedure, mild conditions and good enantiocontrol (51–95% ee), thus providing an important alternative to assemble the challenging atropisomeric aryl‐acyclic alkene scaffolds. magnified image
Topics & Concepts
ChemistryKinetic resolutionStyreneCatalysisTransfer hydrogenationAtropisomerArylEnantioselective synthesisAlkeneCombinatorial chemistryOrganic chemistryCopolymerPolymerAlkylRutheniumAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAlkaloids: synthesis and pharmacology