Type 3 IP3 receptor: Its structure, functions, and related disease implications
Lvying Wu, Jin Chen
Abstract
from the endoplasmic reticulum (ER) in response to extracellular stimuli. The gating of IP3R3 is regulated not only by ligands but also by other interacting proteins. To date, extensive research conducted on the basic structure of IP3R3, as well as its regulation by ligands and interacting proteins, has provided novel perspectives on its biological functions and pathogenic mechanisms. This review aims to discuss recent advancements in the study of IP3R3 and provides a comprehensive overview of the relevant literature pertaining to its structure, biological functions, and pathogenic mechanisms.
Topics & Concepts
Endoplasmic reticulumGatingInositol trisphosphate receptorInositolReceptorExtracellularCell biologyIntracellularBiologyHomeostasisTranscription factorIon channelSignal transductionComputational biologyNeuroscienceBiochemistryGeneCalcium signaling and nucleotide metabolismPancreatic function and diabetesCellular transport and secretion