Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication
Zhuang Wei, Tae Sung Kim, Jong Il Ahn, Lingjun Meng, Yaozong Chen, E. K. RYU, Bonsu Ku, Ming Zhou, Seung Jun Kim, Jeong Kyu Bang, Jan M. van Deursen, Jung‐Eun Park, Kyung S. Lee
Abstract
Thus, Cep57 plays a key role in architecting the Cep63-Cep152 assembly around centriolar MTs and promoting centriole biogenesis. This study may offer a platform to investigate how the organization and function of the pericentriolar architecture are altered by disease-associated mutations found in the Cep57-Cep63-Cep152 complex.
Topics & Concepts
CentrioleBiologyBiogenesisCell biologyBasal bodyGeneticsMicrotubuleFlagellumGeneMicrotubule and mitosis dynamicsNuclear Structure and FunctionUbiquitin and proteasome pathways