A β-allyl carbamate fluorescent probe for vicinal dithiol proteins
Lanning Zhao, Feifei Bai, Fan Chen, Menghuan Guo, Lu Gan, Hong Zhang, Jianguo Fang
Abstract
The first β-allyl carbamate fluorescent probe, AC-green, was reported for specifically imaging vicinal dithiol proteins (VDPs) in living systems. The probe displays low toxicity and features high sensitivity and fast response towards VDPs. A drastic loss of VDPs in a Parkinson's model was disclosed by AC-green, linking the fluctuation of VDP levels to Parkinson's disease for the first time. The structural novelty and favorable properties of AC-green will advance the development of novel VDP probes.
Topics & Concepts
VicinalCarbamateFluorescenceDithiolNoveltyChemistryStereochemistryBiochemistryOrganic chemistryPsychologySocial psychologyPhysicsQuantum mechanicsClick Chemistry and ApplicationsReceptor Mechanisms and SignalingAdenosine and Purinergic Signaling