Brønsted acid-catalyzed cascade cyclization: an efficient strategy for divergent synthesis of cyclohepta[<i>b</i>]indole derivatives
Shaomin Chen, Zhiyan Chen, Tianjian Zhang, Bo Zhao, Bo You, Minghao Li, Yanlong Gu
Abstract
An efficient acid-catalyzed three-component cascade strategy by employing 3,3′-bis(indolyl)methanes (BIMs) as masked 1,4-nucleophiles was established for synthesizing cyclohepta[ b ]indoles under mild and eco-friendly conditions.
Topics & Concepts
Indole testCatalysisCascadeBrønsted–Lowry acid–base theoryChemistryCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryChromatographySynthesis of Indole DerivativesCatalytic C–H Functionalization MethodsMulticomponent Synthesis of Heterocycles