Synthesis and biological activity of squaramido-tethered bisbenzimidazoles as synthetic anion transporters
Zhong‐Kun Wang, Xiao-Qiao Hong, Jinhui Hu, Yuan-Yuan Xing, Wen‐Hua Chen
Abstract
an anion exchange process, and tend to be more active at acidic pH than at physiological pH. The viability of these conjugates toward four selected solid tumor cell lines was evaluated using an MTT assay and the results suggest that some of these conjugates exhibit moderate cytotoxicity probably in an apoptotic fashion.
Topics & Concepts
ChemistryConjugateCytotoxicityChlorideMTT assayTransporterIon exchangeTransmembrane proteinViability assayBiological activityCombinatorial chemistryIonBiochemistryIn vitroOrganic chemistryReceptorMathematical analysisGeneMathematicsMolecular Sensors and Ion DetectionChemical Reaction MechanismsSynthesis and Characterization of Heterocyclic Compounds