Litcius/Paper detail

Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives

Liyu Zhao, Wenbo Yin, Yin Sun, Nannan Sun, Linfeng Tian, Yang Zheng, Chu Zhang, Shizhen Zhao, Xin Su, Dongmei Zhao, Maosheng Cheng

2021European Journal of Medicinal Chemistry19 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryPharmacokineticsMetabolic stabilityBioavailabilityMicrosomeAntifungalCandida albicansIn vitroPharmacologyChemical synthesisMetabolismStereochemistryBiochemistryMicrobiologyMedicineBiologyAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentSynthesis and Biological Evaluation