Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives
Liyu Zhao, Wenbo Yin, Yin Sun, Nannan Sun, Linfeng Tian, Yang Zheng, Chu Zhang, Shizhen Zhao, Xin Su, Dongmei Zhao, Maosheng Cheng
Topics & Concepts
ChemistryPharmacokineticsMetabolic stabilityBioavailabilityMicrosomeAntifungalCandida albicansIn vitroPharmacologyChemical synthesisMetabolismStereochemistryBiochemistryMicrobiologyMedicineBiologyAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentSynthesis and Biological Evaluation