<i>In Vivo</i> Development of Aztreonam Resistance in Meropenem-Resistant Pseudomonas aeruginosa Owing to Overexpression of the <i>bla</i> <sub>PDC-16</sub>
Li Ding, Yue Sun, Yizhuo Zhang, Siquan Shen, Fupin Hu
Abstract
Pseudomonas aeruginosa is notorious for being highly resistant to antimicrobial agents. In this study, two P. aeruginosa strains isolated from the same patient with different susceptibility to aztreonam were used to illustrate the within-host resistance evolution process of P. aeruginosa .
Topics & Concepts
AztreonamPseudomonas aeruginosaMeropenemMicrobiologyIn vivoOperonResistance (ecology)BiologyGeneticsAntibiotic resistanceGeneBacteriaAntibioticsEcologyImipenemEscherichia coliAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingAntibiotics Pharmacokinetics and Efficacy