Recent advances in the application and biological mechanism of silicon nitride osteogenic properties: a review
Ziyi Liu, Ruijie Wang, Wenjing Liu, Yushan Liu, Xiaoli Feng, Fujian Zhao, Pei Chen, Longquan Shao, Mingdeng Rong
Abstract
several mechanisms. Moreover, it may also promote osteogenesis by influencing immune regulation and angiogenesis. In addition, the wettability, surface morphology, and charge of silicon nitride play crucial roles in regulating its osteogenesis-promoting properties. However, as a bioceramic material, the molding process of silicon nitride needs to be optimized, and its osteogenic mechanism must be further investigated. Herein, we summarize the impact of the molding process of silicon nitride on its osteogenic properties and clinical applications. In addition, the mechanisms of silicon nitride in promoting osteogenesis are discussed, followed by a summary of the current gaps in silicon nitride mechanism research. This review, therefore, aims to provide novel ideas for the future development and applications of silicon nitride.