Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection
James B. Doub, Vincent Y. Ng, Aaron J. Johnson, Magdalena Slomka, Joseph Fackler, Bri’Anna Horne, Michael Brownstein, Matthew Henry, Francisco Malagón, Biswajit Biswas
Abstract
This is a case of a 72 year old male with a chronic methicillin-resistant Staphylococcus aureus prosthetic joint infection. After the third intravenous dose of bacteriophage therapy, an unusual, reversible transaminitis prompted stoppage of bacteriophage therapy. Nevertheless, treatment was successful and the patient’s severe chronic infection was eradicated.
Topics & Concepts
MedicineBacteriophageStaphylococcus aureusMethicillin-resistant Staphylococcus aureusChronic infectionStaphylococcal infectionsSalvage therapySurgeryChemotherapyImmunologyBiologyBacteriaGeneImmune systemBiochemistryEscherichia coliGeneticsOrthopedic Infections and TreatmentsBacteriophages and microbial interactionsOrthopaedic implants and arthroplasty