Translational Modeling of Anticancer Efficacy to Predict Clinical Outcomes in a First-in-Human Phase 1 Study of MDM2 Inhibitor HDM201
Nelson Guerreiro, Astrid Jullion, Stéphane Ferretti, Claire Fabre, Christophe Meille
Topics & Concepts
MedicineDosingScheduleOncologyIn vivoCell cyclePharmacologyDrugCancerMdm2PharmacodynamicsInternal medicineCancer researchPharmacokineticsApoptosisBiologyComputer scienceBiotechnologyOperating systemBiochemistryEpigenetics and DNA MethylationCancer-related gene regulationRNA Research and Splicing