Heteroleptic enantiopure Pd(<scp>ii</scp>)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the influence of chirality and halogen atoms on the anticancer activity
Nazanin Kordestani, Hadi Amiri Rudbari, Isabel Correia, Andreia Valente, Leonor Côrte‐Real, Mohammad Khairul Islam, Nicola Micale, Jason D. Braun, David E. Herbert, Nikolay Tumanov, Johan Wouters, Mohammed Enamullah
Abstract
To investigate the effect of chirality and different halogen substituents on the anticancer activity, seven enantiomeric pairs of palladium complexes were synthesized and characterized.
Topics & Concepts
ChemistryEnantiopure drugHalogenChirality (physics)Characterization (materials science)Combinatorial chemistryPolymer chemistryStereochemistryEnantioselective synthesisOrganic chemistryNanotechnologyCatalysisMaterials scienceNambu–Jona-Lasinio modelPhysicsQuantum mechanicsChiral symmetry breakingQuarkAlkylMetal complexes synthesis and propertiesCrystallography and molecular interactionsCrystal structures of chemical compounds