Palladium-Catalyzed Intermolecular Polarity-Mismatched Addition of Unactivated Alkyl Radicals to Unactivated Alkenes
Xiaojin Wu, Guanlin Xiao, Yalan Ding, Ying Zhan, Yao Zhao, Rizhi Chen, Teck‐Peng Loh
Abstract
A palladium-catalyzed intermolecular polarity-mismatched addition of unactivated alkyl radicals to unactivated alkenes was developed for the first time. In the two-component dicarbofunctionalization, a variety of primary, secondary, and tertiary unactivated alkyl halides regioselectively reacted with various unactivated olefins. A series of structurally complex heteropolycycles decorated with a quaternary carbon center have been efficiently synthesized.
Topics & Concepts
AlkylChemistryPalladiumCatalysisIntermolecular forceRadicalPolarity (international relations)HalidePrimary (astronomy)PhotochemistryOrganic chemistryMoleculeAstronomyPhysicsBiochemistryCellCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions