miR-146a regulates emphysema formation and abnormal inflammation in the lungs of two mouse models
Hitomi Yoshikawa, Tadashi Sato, Kimiko Horikoshi, Moegi Komura, Naoko Arano Nitta, Aki Mitsui, Kengo Koike, Yuzo Kodama, Kazuhisa Takahashi
Abstract
This study demonstrates that miR-146a expression is upregulated in mouse lungs because of elastase- and CS-induced emphysema and that the inflammatory response by elastase or CS is enhanced in the lungs of miR-146a-KO mice than in those of control mice, resulting in the promotion of emphysema. This is the first study to evaluate the protective role of miR-146a in emphysema formation and the associated abnormal inflammatory response in different in vivo models.
Topics & Concepts
Bronchoalveolar lavageCOPDElastaseMedicineChemokinePathogenesisInflammationLungNeutrophil elastaseIn vivoImmunologyPancreatic elastasePathologyProinflammatory cytokineInternal medicineChemistryBiologyEnzymeBiochemistryBiotechnologyMicroRNA in disease regulationCircular RNAs in diseasesRNA modifications and cancer