Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects
Xuan Zhang, Gaohua Zhang, Wen-Jing Zhai, Zhijun Zhao, Sheng Wang, Jianfeng Yi
Topics & Concepts
AvermectinMoxidectinIvermectinPharmacologyChemistryApoptosisIC50Cell growthCancer cellGrowth inhibitionIn vitroCancerBiologyBiochemistryGeneticsZoologyAnatomyIon channel regulation and functionIon Channels and ReceptorsNicotinic Acetylcholine Receptors Study