miR-379 mediates insulin resistance and obesity through impaired angiogenesis and adipogenesis regulated by ER stress
Maryam Abdollahi, Mitsuo Kato, Linda Lanting, Ragadeepthi Tunduguru, Mei Wang, Yangmeng Wang, Patrick T. Fueger, Qiong Wang, Wendong Huang, Rama Natarajan
Abstract
) were decreased. These changes, as well as key parameters of brown adipose tissue dysfunction (including mitochondrial defects), were significantly attenuated in miR-379KO-HFD mice. WAT from obese human subjects with and without type 2 diabetes showed increased miR-379 and decreased miR-379 target genes. In cultured 3T3L1 pre-adipocytes, miR-379 inhibitors increased miR-379 targets and adipogenic genes. These data suggest that miR-379 plays an important role in HFD-induced obesity through increased adipose inflammation, mitochondrial dysfunction, and ER stress as well as impaired adipogenesis and angiogenesis. miR-379 inhibitors may be developed as novel therapies for obesity and associated complications.