The substitution sites of hydroxyl and galloyl groups determine the inhibitory activity of human pancreatic α-amylase in twelve tea polyphenol monomers
Lan Zhang, Haocun Kong, Bimal Chitrakar, Xiaofeng Ban, Zhengbiao Gu, Yan Hong, Li Cheng, Zhaofeng Li, Caiming Li
Topics & Concepts
PolyphenolChemistryTheaflavinIC50Docking (animal)Mixed inhibitionInhibitory postsynaptic potentialStereochemistryAmylaseQuantitative structure–activity relationshipGallateBiochemistryEnzymeAntioxidantNon-competitive inhibitionIn vitroBiologyNeuroscienceNursingMedicineNuclear chemistryNatural Antidiabetic Agents StudiesEnzyme Production and CharacterizationAdvanced Glycation End Products research