Targeted Degradation of Oncogenic KRAS <sup>G12C</sup> by VHL-Recruiting PROTACs
Michael J. Bond, Ling Chu, Dhanusha A. Nalawansha, Ke Li, Craig M. Crews
Abstract
cell lines. LC-2 demonstrates that PROTAC-mediated degradation is a viable option for attenuating oncogenic KRAS levels and downstream signaling in cancer cells.
Topics & Concepts
KRASUbiquitin ligaseCancer researchMutantSmall moleculeChemistryMAPK/ERK pathwayMutationUbiquitinCell biologySignal transductionBiologyBiochemistryGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments