Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer
Huijuan Luo, Dongjuan Si, Xin-jie Sun, Mengyun Wang, Yao-bin Yang, Bo Wang, Hongmei Wen, Wěi Li, Jian Li
Topics & Concepts
MDMXMdm2ChemistrySuppressorCancer cellApoptosisCancer researchBiochemistryCancerBiologyGeneGeneticsCancer-related Molecular PathwaysUbiquitin and proteasome pathwaysMicrotubule and mitosis dynamics