AIE-active Ir(<scp>iii</scp>) complexes as type-I dominant photosensitizers for efficient photodynamic therapy
Jialin Tong, Xinyue Yang, Xiaoxian Song, Jie Liang, Shanshan Huang, Huiting Mao, Mansoor Akhtar, Ao Liu, Guo‐Gang Shan, Guangfu Li
Abstract
, Ir(III) PSs MFIrqa, SFIriqa, and SFIrqa nanoparticles show obvious photodynamic activity toward cancer cells upon irradiation accompanied by type I ˙OH generation, which may be attributed to the unique excited-state characteristics of Ir(III) complexes. This work will provide guidance for the construction of a type I photosensitizer based on the AIE-active Ir(III) complex, which offers great advantages for potential clinical applications under hypoxic conditions.
Topics & Concepts
PhotosensitizerIntersystem crossingPhotodynamic therapyAggregation-induced emissionChemistryReactive oxygen speciesPhotochemistryRadicalExcited stateFluorescenceBiochemistryOrganic chemistryPhysicsSinglet stateQuantum mechanicsNuclear physicsLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry