Preparation and characterization of novel anti-inflammatory biological agents based on piroxicam-loaded poly-ε-caprolactone nano-particles for sustained NSAID delivery
Azizeh Rahmani Del Bakhshayesh, Abolfazl Akbarzadeh, Alireza Alihemmati, Hamid Tayefi Nasrabadi, Azadeh Montaseri, Soodabeh Davaran, Ali Abedelahi
Abstract
drug release profiles. Eventually, the NPs synthesized with collagen were conjugated so that the NPs were trapped in the collagen sponges using a cross-linker. Finally, biocompatibility tests showed that the anti-inflammatory agents made in this study had no toxic effect on the cells. Based on the results, it appears that PX-loaded PCL NPs along with collagen (PPCLnp-Coll) can be promising for IA administration based on particulate drug delivery for the treatment of arthritis.
Topics & Concepts
PiroxicamMaterials scienceCaprolactoneNano-JavaScriptDelivery systemZoomClick chemistryComputer scienceBiomedical engineeringCopolymerMedicineComposite materialPolymerProgramming languagePolymer chemistryPhysicsPathologyOpticsLens (geology)Alternative medicineAdvanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug Delivery