Engineering metal-based hydrogel-mediated tertiary lymphoid structure formation <i>via</i> activation of the STING pathway for enhanced immunotherapy
Xiao‐Kang Jin, Jun‐Long Liang, Shi‐Man Zhang, Ping Ji, Qian‐Xiao Huang, You‐Teng Qin, Xin‐Chen Deng, Chuan‐Jun Liu, Xian‐Zheng Zhang
Abstract
A STING-activating hydrogel is developed to evoke a DC-based immune effect and facilitate the activation of the cGAS-STING and TLR9 pathways at tumor sites, further enhancing the infiltration of immune cells for the formation of TLSs.
Topics & Concepts
TLR9Immune systemImmunotherapyChemokineStingTumor microenvironmentCancer researchImmunogenic cell deathStimulator of interferon genesInnate immune systemImmunologyCell biologyChemistryBiologyGene expressionDNA methylationBiochemistryEngineeringGeneAerospace engineeringinterferon and immune responsesImmune Cell Function and InteractionImmunotherapy and Immune Responses