Efficacy of a Third-Generation Oncolytic Herpes Virus G47Δ in Advanced Stage Models of Human Gastric Cancer
Kotaro Sugawara, Miwako Iwai, Shoh Yajima, Minoru Tanaka, Kazuyoshi Yanagihara, Yasuyuki Seto, Tomoki Todo
Abstract
PFU) was constantly efficacious whether administered intratumorally or intraperitoneally in the clinically relevant models. Notably, G47Δ injected intraperitoneally readily distributed to, and selectively replicated in, disseminated tumors. Furthermore, flow cytometric analyses of tumor-infiltrating cells in subcutaneous tumors revealed that intratumoral G47Δ injections markedly decreased M2 macrophages while increasing M1 macrophages and natural killer (NK) cells. These findings indicate the usefulness of G47Δ for treating human gastric cancer, including scirrhous gastric cancer and the ones in advanced stages.
Topics & Concepts
Oncolytic virusCancerMedicineStage (stratigraphy)Cancer cellIn vivoPathologyHerpes simplex virusVirusInternal medicineBiologyImmunologyBiotechnologyPaleontologyVirus-based gene therapy researchHerpesvirus Infections and TreatmentsCAR-T cell therapy research