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Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies

Nawaf A. Alsaif, Mohammed S. Taghour, Mohammed M. Alanazi, Ahmad J. Obaidullah, Wael A. Alanazi, Abdullah F. Alasmari, Hussam Albassam, Mohammed A. Dahab, Hazem A. Mahdy

2021Bioorganic & Medicinal Chemistry34 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIn silicoTyrosine kinaseStereochemistryKinaseStructure–activity relationshipIn vitroBiochemistryCombinatorial chemistryPharmacologySignal transductionGeneMedicineSynthesis and Biological EvaluationBioactive Compounds and Antitumor AgentsSynthesis and biological activity
Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies | Litcius