Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types
Sara Sáez-Atiénzar, Sara Bandrés‐Ciga, Rebekah G. Langston, Jonggeol J. Kim, Shing Wan Choi, Regina H. Reynolds, ITALSGEN, Yevgeniya Abramzon, Ramita Dewan, Sarah Ahmed, John E. Landers, Ruth Chia, Mina Ryten, Mark Cookson, Michael A. Nalls, Adriano Chiò, Bryan J. Traynor
Abstract
) within the significant pathways as relevant to ALS. We conclude that the disparate genetic etiologies of this fatal neurological disease converge on a smaller number of final common pathways and cell types.
Topics & Concepts
Amyotrophic lateral sclerosisPathogenesisCell typeNeuroscienceBiologyCellMedicineGeneticsDiseasePathologyImmunologyAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchCancer-related gene regulation