Oxidation-responsive PEG-poly(α-lipoic acid) nanoparticles for coenzyme Q<sub>10</sub> delivery attenuate hepatic ischemia-reperfusion injury <i>via</i> ROS scavenging and ferroptosis inhibition
Yu Guan, Jinyu Liu, Jing Yang, Sufang Chen, Weifeng Yao, Shengyuan Gong, Chunsheng Xiao, Mingqiang Li, Gangjian Luo, Ziqing Hei
Abstract
nanoparticle is a novel antioxidant nanomedicine that synergistically attenuates ROS-mediated damage and ferroptotic cell death in hepatic IRI. These findings highlight a promising strategy for protecting organs from ischemia-reperfusion damage by targeting oxidative stress and ferroptosis with responsive biomaterial carriers.
Topics & Concepts
Coenzyme Q10Lipoic acidPEG ratioReactive oxygen speciesScavengingPharmacologyReperfusion injuryNanoparticleIschemiaBiochemistryChemistryMaterials scienceAntioxidantMedicineNanotechnologyInternal medicineEconomicsFinanceCoenzyme Q10 studies and effectsBiochemical effects in animalsLiver Disease and Transplantation