Evaluating the Pharmacokinetics of Fentanyl in the Brain Extracellular Fluid, Saliva, Urine, and Plasma of Newborns from Transplacental Exposure from Parturient Mothers Dosed with Epidural Fentanyl Utilizing PBPK Modeling
Mo’tasem M. Alsmadi
Topics & Concepts
Physiologically based pharmacokinetic modellingPharmacokineticsFentanylTransplacentalMedicineUrineAnesthesiaAnesthesiologyPharmacologyExtracellular fluidPregnancyFetusChemistryInternal medicineExtracellularPlacentaBiologyBiochemistryGeneticsPrenatal Substance Exposure EffectsAnesthesia and Pain ManagementMaternal Mental Health During Pregnancy and Postpartum