Structure and function relationship of formate dehydrogenases: an overview of recent progress
Ami Kobayashi, M. Taketa, Keisei Sowa, Kenji Kano, Yoshiki Higuchi, Hideaki Ogata
Abstract
Formate dehydrogenases (FDHs) catalyze the two-electron oxidation of formate to carbon dioxide. FDHs can be divided into several groups depending on their subunit composition and active-site metal ions. Metal-dependent (Mo- or W-containing) FDHs from prokaryotic organisms belong to the superfamily of molybdenum enzymes and are members of the dimethylsulfoxide reductase family. In this short review, recent progress in the structural analysis of FDHs together with their potential biotechnological applications are summarized.
Topics & Concepts
FormateSUPERFAMILYEnzymeChemistryBiochemistryCatalysisGeneMetalloenzymes and iron-sulfur proteinsMetal-Catalyzed Oxygenation MechanismsEnzyme Catalysis and Immobilization