Carboxylesterase-2 plays a critical role in dabigatran etexilate active metabolite formation
S. Casey Laizure, Feng Chen, Julie E. Farrar, Dina A. Ali, Bing Yang, Robert B. Parker
Topics & Concepts
CarboxylesteraseMetaboliteActive metaboliteChemistryProdrugPharmacologyMicrosomeIC50EnzymeIn vitroBiochemistryBiologyCholinesterase and Neurodegenerative DiseasesPharmacogenetics and Drug MetabolismComputational Drug Discovery Methods