Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation
Shin Ishihara, Hidetaka Yamamoto, Takeshi Iwasaki, Yu Toda, Takeo Yamamoto, Masato Yoshimoto, Yoshihiro Ito, Yousuke Susuki, Kengo Kawaguchi, Izumi Kinoshita, Yuichi Yamada, Kenichi Kohashi, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yuko Kakuda, Yasuharu Nakashima, Yoshinao Oda
Topics & Concepts
ImmunohistochemistryPathologyBiologyGiant-cell tumor of boneHistone H3Fluorescence in situ hybridizationGiant cellEZH2Comparative genomic hybridizationCancer researchHistoneMedicineGeneticsChromosomeGeneBone Tumor Diagnosis and TreatmentsOral and Maxillofacial PathologySarcoma Diagnosis and Treatment