Benzimidazole(s): synthons, bioactive lead structures, total synthesis, and the profiling of major bioactive categories
Lotfi M. Aroua, Fahad M. Alminderej, Hind R. Almuhaylan, Abdulelah H. Alosaimi, Faten Medini, Hamdoon A. Mohammed, Suliman A. Almahmoud, Riaz A. Khan, Nejib Hussein Mekni
Abstract
, antibacterial, antitubercular, antidiabetic, anticancer, antifungal, anti-inflammatory, analgesic, antioxidant, antihistaminic, and antimalarial activity, has led us to take note and provide an overview of the synthetic development approaches for various benzimidazole derivatives together with their biological actions. This review is projected to further assist in the design and development of new benzimidazole-based compounds for new and optimized pharmacologically active products towards new drug-development strategies.
Topics & Concepts
SynthonBenzimidazoleProfiling (computer programming)ChemistryCombinatorial chemistryNanotechnologyComputer scienceOrganic chemistryMaterials scienceProgramming languageSynthesis and biological activitySynthesis of heterocyclic compoundsClick Chemistry and Applications