One-pot synthesis of 3-trifluoromethylbenzo[<i>b</i>][1,4]oxazines from CF<sub>3</sub>-imidoyl sulfoxonium ylides with 2-bromophenols
Mingshi Pan, Yixin Tong, Xiaodong Qiu, Xiaobao Zeng, Biao Xiong
Abstract
A one-pot two-step fashion for the synthesis of 3-trifluoromethyl-1,4-benzoxazines from CF 3 -imidoyl sulfoxonium ylides and 2-bromophenols via lithium-bromide-promoted O–H insertion of sulfoxonium ylides and annulation has been demonstrated.
Topics & Concepts
AnnulationTrifluoromethylSubstrate (aquarium)Combinatorial chemistryScope (computer science)SimplicityChemistryLithium (medication)BromideSequence (biology)Organic chemistryComputer scienceCatalysisBiologyProgramming languagePhysicsEcologyBiochemistryEndocrinologyAlkylQuantum mechanicsFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods