Discovery of novel antibacterial agent for the infected wound treatment: all-hydrocarbon stapling optimization of LL-37
Yanan Zhang, Mengjun Zheng, Zhe Wang, Zhinan Liu, Sumeng Chen, Xiang Li, Yejiao Shi, Honggang Hu
Abstract
) could serve as a lead compound for the clinical treatment of bacterial infections.
Topics & Concepts
AntimicrobialAntibacterial activityAntibioticsChemistryAntimicrobial peptidesBacteriaPeptideCombinatorial chemistryCytotoxicityAntibacterial peptideBroad spectrumBiochemistryMicrobiologyBiologyOrganic chemistryIn vitroGeneticsAntimicrobial Peptides and ActivitiesBiochemical and Structural CharacterizationProtein Hydrolysis and Bioactive Peptides