Highly water-dispersible PCN nanosheets as light-controlled lysosome self-promoting escape type non-cationic gene carriers for tumor therapy
Mingxuan Liu, Xiaoling Zhang, Jingbo Yang, Zhong‐Lin Lu, Qitao Zhang
Abstract
experiments further confirmed that PCN nanosheets loaded with the P53 gene were beneficial to the regeneration of the P53 apoptotic pathway, increased tumor sensitivity to PSs, and further induced tumor cell apoptosis. In summary, the highly water-dispersible PCN nanosheets were applied to light-controlled self-escaping gene delivery for the first time, and tumor gene therapy was successfully realized.
Topics & Concepts
LysosomeCationic polymerizationGenetic enhancementMaterials scienceGene deliveryGeneNanotechnologyCancer researchMedicineBiochemistryBiologyPolymer chemistryEnzymeRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesGraphene and Nanomaterials Applications